Can Rutin be Used as An Antidote for Acute Acetaminophen Induced Hepatic Toxicity? An Experimental Study

Document Type : Original Article

Authors

1 Department of Forensic Medicine & Clinical Toxicology , Faculty of Medicine, Mansoura University, Egypt

2 Forensic Med. & Clin. Toxicology, Mansoura Faculty of Medicine, Egypt

3 Forensic Medicine & Clinical Toxicology Department,Faculty of Medicine, Mansoura University

4 Department of Pathology, Faculty of Medicine, Mansoura University, Egypt

Abstract

Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose of APAP remains a significant clinical problem. This study aimed to assess the use of rutin in the treatment of acute acetaminophen toxicity compared to N-acetyl cysteine (NAC) in mice. Sixty mice were divided into 6 groups; group (1) as a control group, group (2) was given toxic dose of acetaminophen 250 mg/kg once by intraperitoneal injection "i.p.", group (3) was given N-acetyl cysteine 204 mg/kg once i.p., group (4) was given 28 mg/kg rutin once orally, group (5) was given toxic dose of acetaminophen followed by N-acetyl cysteine after one hour once i.p. and group (6) was given toxic dose of acetaminophen followed after one hour by four oral doses of rutin at 12 h intervals. Animals were sacrificed 12h after the last treatment. Alanine transaminase (ALT) was measured and liver was removed and examined histopathologically. Results showed that acute acetaminophen hepatotoxicity was best treated by multiple doses of rutin rather than single dose of NAC. It is concluded that rutin can be used in treatment of acetaminophen induced acute hepatic toxicity. 

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