Plasma Brain Derived Neurotrophic Factor Level and Its Gene Polymorphism in Toxic Suicidal Behavior

Document Type : Original Article

Authors

1 Forensic Medicine & Clinical Toxicology Department, Mansoura Faculty of Medicine, Egypt

2 Forensic Medicine & Clinical Toxicology Department, Mansoura Faculty of Medicine, Egypt.

3 Clinical Pathology Department, Mansoura Faculty of Medicine, Egypt.

Abstract

Suicide represents a major health problem, it is suggested that multiple factors influence the rate of suicide. Brain derived neurotrophic factor (BDNF) is considered a reliable biological marker of suicide. Its level decreases in all suicidal victims whether or not they are suffering from psychiatric troubles. The objective of this work was to compare BDNF levels and single nucleotide polymorphism in suicidal and non-suicidal groups to explore whether suicide is related to BDNF related mechanisms. Plasma BDNF levels were screened in conjunction with tracking of the 196 G/A (val66met, rs6265) polymorphism in 89 suicidal patients that visited the toxicology unit and 89 control. The pattern of gene polymorphism did not show significant differences between suicidal patients and control. However, the plasma BDNF levels were higher in suicidal cases. It can be concluded that the combined assessment of BDNF showed no difference in genotyping between suicide and control groups. However, higher levels of plasma BDNF were detected in the samples taken from suicide attempters.

Keywords

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Volume 26, Issue 1
January 2018
Pages 53-63

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