Leucocytes' Parameters for Prediction of the Complications of Acute Corrosive Toxicity

Document Type : Original Article


1 Forensic Medicine and Clinical Toxicology Department - Faculty of Medicine, Tanta University, Tanta- Egypt

2 Clinical Pathology Department - Faculty of Medicine, Tanta University-Tanta- Egypt.


Acute corrosive toxicity is a serious problem in clinical toxicology as it may be associated with severe complications. Prediction of complications related to corrosive toxicity is very important for better management and outcome. Inflammation is considered a predisposing factor for the development of corrosive toxicity complications. Leucocytes are a component of the inflammatory process. The aim of this study is to evaluate leucocytes' parameters as predictors for complications of acute corrosive toxicity. Forty four patients with acute corrosive toxicity were subjected to history taking (personal and toxicological), general and local oral examination. A venous blood sample was obtained from each participant. Total and differential leucocyte counts together with neutrophil-to-lymphocyte ratio were obtained. Total leucocyte count, neutrophil count and neutrophil-tolymphocyte ratio were good predictors for complications at cut off > 15100/mm3, > 9308/mm3 and > 2.42 respectively. It is concluded that total leucocyte count, neutrophil count and neutrophil-to-lymphocyte ratio could serve as good predictor markers for corrosive toxicity complications.