Protective Effect of L- Carnitine Against Formaldehyde-Induced Kidney, Liver and Testicular Damage in Rabbits, A Histopathological Study

Document Type : Original Article

Authors

1 Forensic and Clinical Toxicology Department, Assiut University

2 Theriogenology Department, Faculty of Veterinary, Assiut University

3 Pathology Department, Faculty of Medicine, Assiut University.

Abstract

Formaldehyde (dissolved in market milk) was given every day by gavage to male rabbits for 90 days and the histological changes in the liver, kidney and testicles were examined using paraffin method. This compound has caused hepatotoxicity which included portal inflammation and infiltration by mononuclear inflammatory cells of the hepatocytes. This compound has also caused nephrotoxicity which included tubular dilatation and hydropic degeneration of tubular epithelial cells. The effect on the testicles included atrophy of some seminiferous tubules with shedding of disintegrated epithelial cells into the lumina as well as decrease in the number of the sperms. When given to the formalin exposed rabbits, L-Carnitine caused recovery of the changes in the liver, kidneys and testicles i.e. it has been succeeded in playing a protective role against formalin hepatotoxicity, nephrotoxicity and testicular damage.

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