Osteoporosis and the Duration of Coca•Cola Consumption Relationship in Female Albino Rats

Document Type : Original Article


Department of Zoology, Faculty of Science, Mansoura University, Egypt


Coca-cola beverage is one of the risk factors resulting in calcium deficiencies and an increased risk of osteoporosis in rats. The objective of this study is the comparing between five and seven months of coca-cola consumption on osteoporosis markers. The obtained data suggested that orally coca-cola consumption (5ml/Kg/day) cause a significant increase in minerals (calcium and phosphorus) level, in both serum and urine while a significant decrease in the level of these minerals in bone was recorded specially in seven months rats group. At the same time, significant increases in serum and urine creatinine, urea and creatinine ratio as well as parathyroid hormone level, while a decrease in the level of calcitonine as well as in the total protein content were observed. In addition, a significant increase in the level of bone marker enzymes (alkaline and acid phosphatase) activity was recorded, indicating an increase in bone turnover rate. A significant increase was observed in femur water content in rats received cocacola, meanwhile, bone mineral density was significantly decreased. All these parameters are more pronounced at seven months group than those of five months only. Thus, it was concluded that the long-term consumption of coca-cola is strongly associated with the development of osteoporosis evidenced by the occurred changes in the estimated bone marker parameters.