Immunotoxicity of Some Pesticides in Egyptian Diabetic Children

Document Type : Original Article

Authors

1 Forensic Medicine & Clinical Toxicology, Mansoura University, Egypt

2 Department of Forensic Medicine and Clinical Toxicology; Faculty of Medicine, Mansoura University, Egypt

3 Department of Clinical Pathology; Faculty of Medicine, Mansoura University, Egypt.

4 Mansoura University Children Hospital, Faculty of Medicine, Mansoura University, Egypt.

Abstract

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder that could be triggered by environmental pollutants in genetically susceptible individuals. The present study aimed to assess the immune response of different lymphocyte subpopulations in a group of diabetic children in relation to pesticides with highest Odds ratios (lindane and malathion).  One hundred and ten Egyptian children; their ages ranged from 1.2 to 10 years were studied. The control group comprised 35 healthy children, while the study group included 75 children (diagnosed as T1DM within the first month). Seven whole peripheral blood sample was collected from each child and was divided as follows: 5 ml blood was taken for toxicological analysis of pesticides residues using Gas Chromatography equipped with Ni63 Electron Capture Detector. The remaining 2 ml blood sample was collected in EDTA tubes and used immediately for testing immunological markers by using flowcytometry. The results revealed significant correlation as regards the expression of CD4 %, HLADR % and CD4/CD8 ratio in relation to lindane. While malathion (an organophosphate compound), shows a significant correlation with CD4 %, CD20 %, CD16 % and HLDAR % lymphocyte subsets in the diabetic group compared to healthy subjects. It is concluded that pesticides might play a role concerning the increased incidence of T1DM in children. 

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