Intravenous Lipid Emulsion Adverse Effect of Haloperidol Toxicity: Biochemical and Histopathological Investigations in Albino Rats

S. Ghaleb, Sherien; Abd Elwahab Hassan, Dalia; M. Sayedc, Marawa; A.Alroby, Fadwa

doi:10.21608/mjfmct.2020.21078.1007

Intravenous Lipid Emulsion Adverse Effect of Haloperidol Toxicity: Biochemical and Histopathological Investigations in Albino Rats

Document Type : Original Article

Authors

¹ Forensic Medicine and Clinical Toxicology Department, Cairo University

² Forensic Medicine and Clinical Toxicology Department, Beni-Suef University, Egypt

³ Pathology Department, Beni-Suef University

10.21608/mjfmct.2020.21078.1007

Abstract

Haloperidol is one of the classic antipsychotic, was the cause of many cases of intoxication in several studies. Intravenous lipid emulsion is the first choice of treatment of Haloperidol toxicity because of the Haloperidol properties, such as high lipid solubility and water-soluble metabolites with low pharmacological activity. The first group was served as control. The second group was treated with different doses of intravenous lipid emulsion. The third group received a single dose of Haloperidol intraperitoneal and the fourth group received a single dose of Haloperidol intraperitoneal followed by different doses of intravenous lipid emulsion. Biochemical investigation as liver and kidney function and CPK were done. The collected tissue sections from kidney, liver and brain were used for histopathological examination. There was elevation in liver function tests in the group treated with Haloperidol and decrease of these levels in the groups that treated by combination of Haloperidol and intravenous lipid emulsion especially in-group (intravenous lipid emulsion dose 10 ml / kg)but there was synergistic effect in-group (intravenous lipid emulsion dose 19 ml / kg). Hepatic and renal tissue in haloperidol group showed marked changes by histopathology also the haloperidol treated group showed significant diffuse changes in the brain histopathology compared to the control group. The treatment of haloperidol intoxication with dose of 10 mL/kg of intravenous lipid emulsion could significantly decrease in ALT and AST. The treatment of haloperidol intoxication with intravenous lipid emulsion could significantly cause improvement of pathology of liver, kidney and brain.

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